WNT2B

Across TCGA pan-cancer cohorts, WNT2B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WNT2B data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WNT2B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WNT2B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where WNT2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.938	0.620	.027	5	view →
HNSC	OS	Quartile	All	0.677	1.000	.030	4	view →
PDAC	OS	Quartile	II,III,IV	0.318	0.713	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WNT2B–LSCC (DFS)

Open the LSCC breakdown →