WNT2B

Across TCGA patient cohorts, WNT2B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT2B-associated genes across cancer lineages are ATM, ACC1, and eEF2. Each is linked with WNT2B in more than 2 cancer types. Because this analysis shows association rather than direction, both WNT2B-to-partner and partner-to-WNT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WNT2B-low versus WNT2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2B→partner) and Y-score (partner→WNT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.527	-2.571	<.001	.010	3	3
UCEC	ACC1 →	+0.330	+2.598	.010	.005	3	2
UCEC	eEF2 →	+0.373	+1.662	.003	.011	3	1
UCEC	EGFR_pY1068 →	-0.259	-1.906	.003	.015	3	1
UCEC	eIF4E →	+0.179	+3.335	.016	.005	3	1
UCEC	A-Raf_pS299 →	-0.130	-1.700	.002	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ATM by WNT2B expression — UCEC

Explore this box plot interactively →