WNT2B

Across TCGA cell cohorts, WNT2B mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT2B-associated genes across cancer lineages are OR4M1, RBMY1A1, and MOG. Each is linked with WNT2B in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT2B-to-partner and partner-to-WNT2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by WNT2B-low versus WNT2B-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT2B→partner) and Y-score (partner→WNT2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR4M1 →	+0.018	+5.169	.007	.005	3	1
BREAST	RBMY1A1 →	+0.006	+5.781	<.001	.001	3	1
LARGE_INTESTINE	MOG →	+0.095	+3.376	.002	.002	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+4.029	.002	.001	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	OPRPN →	+0.043	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR4M1 by WNT2B expression — BREAST

Explore this box plot interactively →