WNT11

Across TCGA pan-cancer cohorts, WNT11 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of WNT11’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where WNT11 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WNT11 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where WNT11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNT11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−0.714	<.001	8	view →
LSCC	Male	III,IV	−0.649	<.001	7	view →
HNSC	Male	II,III,IV	−0.364	.004	5	view →
PDAC	Male	All	−0.655	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

WNT11–LUAD

Open the LUAD breakdown →