WNT11

Across TCGA patient cohorts, WNT11 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNT11-associated genes across cancer lineages are ATM, EGFR_pY1068, and Fibronectin. Each is linked with WNT11 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNT11-to-partner and partner-to-WNT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by WNT11-low versus WNT11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT11→partner) and Y-score (partner→WNT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.618	-3.700	.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.343	-4.000	.001	<.001	3	2
COAD	Fibronectin →	+0.769	+2.815	.006	.036	3	1
COAD	4E-BP1 →	+0.239	+2.815	.047	.036	2	2
UCEC	eEF2 →	+0.334	+2.222	.027	.011	3	1
UCEC	EGFR →	-0.145	-1.700	.032	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by WNT11 expression — UCEC

Explore this box plot interactively →