WNT11

Across TCGA cell cohorts, WNT11 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNT11-associated genes across cancer lineages are CFHR2, GUCY2F, and DDX25. Each is linked with WNT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT11-to-partner and partner-to-WNT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by WNT11-low versus WNT11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT11→partner) and Y-score (partner→WNT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	2
LARGE_INTESTINE	GUCY2F →	+0.008	+2.688	<.001	.008	3	1
LARGE_INTESTINE	DDX25 →	+0.115	+3.254	<.001	.007	3	1
LARGE_INTESTINE	HTR1B →	+0.049	+2.766	<.001	.005	3	1
LARGE_INTESTINE	RASGEF1C →	+0.202	+3.555	.007	.003	3	1
LARGE_INTESTINE	TGM7 →	+0.017	+2.688	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

CFHR2 by WNT11 expression — BLOOD_Leukemia

Explore this box plot interactively →