WNT1

Across TCGA patient cohorts, WNT1 protein abundance is significantly associated with the go_rna of many other GO terms, with 89 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible WNT1-associated GO terms across cancer lineages are L-leucine transport, Long-chain fatty acid import across plasma membrane, and Regulation of protein autoubiquitination. Each is linked with WNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT1-to-partner and partner-to-WNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-leucine transport grouped by WNT1-low versus WNT1-high in PDAC.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT1→partner) and Y-score (partner→WNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	L-leucine transport →	-0.127	-0.415	<.001	.009	3	1
PDAC	Long-chain fatty acid import across plasma membrane →	-0.048	-0.415	.001	.009	3	1
PDAC	Regulation of protein autoubiquitination →	-0.055	-0.415	.002	.009	3	1
PDAC	Negative regulation of vascular associated smooth muscle cell proliferation →	+0.090	+0.415	.006	.009	3	1
PDAC	Glutamatergic neuron differentiation →	-0.117	-0.415	.001	.009	3	1
PDAC	Postsynaptic membrane organization →	-0.077	-0.415	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

L-leucine transport by WNT1 expression — PDAC

Explore this box plot interactively →