WNT1

Across TCGA patient cohorts, WNT1 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible WNT1-associated genes across cancer lineages are RNU6-937P, RNU6-832P, and DUTP8. Each is linked with WNT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNT1-to-partner and partner-to-WNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-937P grouped by WNT1-low versus WNT1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT1→partner) and Y-score (partner→WNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-937P →	+0.318	+5.108	<.001	.008	3	2
SKCM	RNU6-832P →	+0.373	+7.816	<.001	.008	3	1
LIHC	DUTP8 →	+0.061	+5.647	.001	.004	3	1
LIHC	SLC35C2P1 →	+0.050	+5.758	<.001	.003	3	1
LIHC	FTLP16 →	+0.117	+5.033	<.001	.009	3	1
LIHC	MTND1P4 →	+0.071	+5.355	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RNU6-937P by WNT1 expression — LIHC

Explore this box plot interactively →