WNT1

Across TCGA cell cohorts, WNT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 517 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WNT1-associated GO terms across cancer lineages are Cell proliferation in midbrain, Vesicle targeting, and Protein-DNA complex assembly. Each is linked with WNT1 in more than 5 cancer types. Because this analysis shows association rather than direction, both WNT1-to-partner and partner-to-WNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell proliferation in midbrain grouped by WNT1-low versus WNT1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT1→partner) and Y-score (partner→WNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Cell proliferation in midbrain →	+0.170	+0.166	<.001	.002	3	6
LARGE_INTESTINE	Vesicle targeting →	+0.038	+0.051	.001	.004	3	5
SKIN	Protein-DNA complex assembly →	+0.035	+0.024	<.001	.006	3	4
LUNG_NSCLC_LUSC	Response to arsenic-containing substance →	+0.082	+0.032	.001	.003	3	4
LARGE_INTESTINE	Regulation of myoblast fusion →	+0.046	+0.031	.008	.007	2	5
LARGE_INTESTINE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.048	+0.026	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 517 associations by consensus.

Cell proliferation in midbrain by WNT1 expression — CNS

Explore this box plot interactively →