WNT1

Across TCGA cell cohorts, WNT1 mutation is significantly associated with the mutation status of many other genes, with 1,102 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WNT1-associated genes across cancer lineages are SPEF2, CCDC73, and PLAGL2. Each is linked with WNT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNT1-to-partner and partner-to-WNT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEF2 grouped by WNT1-low versus WNT1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNT1→partner) and Y-score (partner→WNT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPEF2 →	+4.807	+4.807	.008	.008	1	3
STOMACH	CCDC73 →	+4.807	+4.807	.008	.008	1	3
SKIN	PLAGL2 →	+4.824	+5.392	.004	.004	1	3
BLOOD_Leukemia	GALNT8 →	+2.870	+3.347	.009	.009	1	3
BLOOD_Leukemia	DCST2 →	+3.799	+5.531	<.001	<.001	1	3
SKIN	SYT3 →	+4.239	+5.053	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,102 associations by consensus.

SPEF2 by WNT1 expression — STOMACH

Explore this box plot interactively →