WNK4

Across TCGA pan-cancer cohorts, WNK4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated WNK4 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher WNK4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated WNK4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

ACC, KIRC, and LIHC are the cancer types where WNK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
KIRC	DFS	Median	All	0.180	0.796	.001	30	view →
LIHC	DFS	Median	II,III,IV	0.040	0.427	<.001	12	view →
UCEC	DFS	Median	All	0.969	0.621	.006	10	view →
CESC	OS	Median	II,III,IV	0.534	0.829	.033	6	view →
LGG	DFS	Median	All	0.192	0.738	.005	6	view →
HNSC	OS	Median	All	0.819	0.348	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

WNK4–ACC (DFS)

Open the ACC breakdown →