Across TCGA patient cohorts, WNK3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,236 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WNK3-associated proteins across cancer lineages are UCHL1, SARM1, and SRSF12_S146. Each is linked with WNK3 in more than 5 cancer types. Because this analysis shows association rather than direction, both WNK3-to-partner and partner-to-WNK3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK3→partner) and Y-score (partner→WNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UCHL1 →	+1.705	+0.871	<.001	<.001	3	6
UCEC	SARM1 →	+0.470	+0.748	<.001	<.001	3	5
LSCC	SRSF12_S146 →	+1.029	+0.952	.002	.002	3	5
GBM	NBEAL2 →	-0.350	-0.415	<.001	<.001	3	5
GBM	ZMYM3 →	+0.338	+0.583	<.001	<.001	3	5
GBM	ZMYM4 →	+0.263	+0.421	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,236 associations by consensus.

Exploration

WNK3 survival (RNA) · tumor vs normal (RNA) · all WNK3 data types