Across TCGA patient cohorts, WNK3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,489 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WNK3-associated genes across cancer lineages are USP1, FKBP3, and PNN. Each is linked with WNK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNK3-to-partner and partner-to-WNK3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK3→partner) and Y-score (partner→WNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	USP1 →	+1.413	+1.459	<.001	.006	3	3
LUAD	FKBP3 →	+1.243	+2.003	.006	<.001	3	2
LUAD	PNN →	+1.411	+1.764	.004	.001	3	2
LUAD	SCML2 →	+1.256	+2.044	.002	<.001	3	2
LUAD	USP11 →	+0.786	+2.094	.002	<.001	3	2
LUAD	HNRNPL →	+0.591	+1.684	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,489 associations by consensus.

Exploration

WNK3 survival (RNA) · tumor vs normal (RNA) · all WNK3 data types