Across TCGA patient cohorts, WNK3 mutation is significantly associated with the RNA expression of many other genes, with 4,746 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK3-associated genes across cancer lineages are CXCL10, ITGAE, and MIR7854. Each is linked with WNK3 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNK3-to-partner and partner-to-WNK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK3→partner) and Y-score (partner→WNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL10 →	+0.869	+1.688	<.001	<.001	3	4
UCEC	ITGAE →	+0.504	+2.058	<.001	<.001	3	4
BLCA	MIR7854 →	+0.891	+4.226	<.001	<.001	3	3
CESC	TRDC →	+1.261	+3.184	.005	.009	3	3
HNSC	SPDYE2B →	+0.168	+2.575	<.001	.002	3	3
HNSC	RNU4-42P →	+0.560	+2.476	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,746 associations by consensus.

Exploration

WNK3 survival (RNA) · tumor vs normal (RNA) · all WNK3 data types