Across TCGA patient cohorts, WNK3 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK3-associated genes across cancer lineages are Cyclin-E2, ATM, and EGFR_pY1068. Each is linked with WNK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both WNK3-to-partner and partner-to-WNK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK3→partner) and Y-score (partner→WNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Cyclin-E2 →	+0.346	+2.817	.002	.037	3	3
UCEC	ATM →	-0.304	-1.649	.009	.009	3	3
UCEC	EGFR_pY1068 →	-0.182	-1.415	.004	.008	3	2
UCEC	eIF4E →	+0.107	+2.100	.049	.002	3	2
COAD	INPP4B →	-0.487	-3.000	.005	.034	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.330	-1.169	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Exploration

WNK3 survival (RNA) · tumor vs normal (RNA) · all WNK3 data types