Across TCGA cell cohorts, WNK3 mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WNK3-associated genes across cancer lineages are PRRC1, CCDC149, and CCDC182. Each is linked with WNK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WNK3-to-partner and partner-to-WNK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK3→partner) and Y-score (partner→WNK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRRC1 →	+0.757	+3.087	<.001	.006	3	2
LARGE_INTESTINE	CCDC149 →	+1.137	+3.169	<.001	.009	3	2
STOMACH	CCDC182 →	+0.033	+5.285	<.001	.003	3	2
OVARY	MLN →	+0.890	+5.807	<.001	.001	3	1
LUNG_SCLC	OR51I1 →	+0.052	+4.256	<.001	.002	3	1
LUNG_SCLC	OR52E2 →	+0.125	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

Exploration

WNK3 survival (RNA) · tumor vs normal (RNA) · all WNK3 data types