WNK2

Across TCGA pan-cancer cohorts, WNK2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WNK2 data layer compared with 20 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WNK2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated WNK2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and HNSC are the cancer types where WNK2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.586	0.297	.017	21	view →
LUAD	OS	Tertile	III,IV	1.000	0.389	.013	18	view →
HNSC	OS	Quartile	II,III,IV	0.814	0.960	.027	7	view →
UCEC	DFS	Tertile	All	0.950	0.760	.023	4	view →
GBM	DFS	Quartile	All	0.856	0.610	.010	4	view →
LSCC	OS	Tertile	All	1.000	0.812	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WNK2–PDAC (OS)

Open the PDAC breakdown →