WNK2

Across TCGA pan-cancer cohorts, WNK2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of WNK2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where WNK2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WNK2 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where WNK2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WNK2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.527	<.001	10	view →
PDAC	Female	All	−1.768	<.001	8	view →
LSCC	Male	All	+1.018	<.001	8	view →
LUAD	Male	All	+0.594	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

WNK2–COAD

Open the COAD breakdown →