WNK2

Across TCGA patient cohorts, WNK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 24,916 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WNK2-associated proteins across cancer lineages are WNK2_S1862, WNK2_S560, and MVP. Each is linked with WNK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both WNK2-to-partner and partner-to-WNK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WNK2 versus WNK2_S1862 in LSCC, with a Pearson correlation of 0.70.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK2→partner) and Y-score (partner→WNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WNK2_S1862 →	+1.296	+1.769	<.001	<.001	3	7
LSCC	WNK2_S560 →	+1.844	+1.983	<.001	<.001	3	5
HNSC	MVP →	-0.418	-1.334	<.001	<.001	3	5
GBM	ZYX →	-0.353	-0.881	<.001	<.001	3	5
GBM	ZYX_S143 →	-0.723	-0.911	<.001	.001	3	5
HNSC	PHC1_S664 →	+0.668	+1.419	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,916 associations by consensus.

WNK2 vs WNK2_S1862 — LSCC

Explore this scatter interactively →