WNK2

Across TCGA patient cohorts, WNK2 protein abundance is significantly associated with the RNA expression of many other genes, with 17,331 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WNK2-associated genes across cancer lineages are PODXL2, MCF2L, and STOX1. Each is linked with WNK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both WNK2-to-partner and partner-to-WNK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WNK2 versus PODXL2 in HNSC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK2→partner) and Y-score (partner→WNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PODXL2 →	+1.658	+0.638	<.001	<.001	3	5
OV	MCF2L →	+0.936	+0.609	<.001	.009	3	5
HNSC	STOX1 →	+1.193	+0.783	.002	<.001	3	5
HNSC	KCNG3 →	+1.270	+0.958	<.001	<.001	3	5
HNSC	CLCN2 →	+0.667	+0.680	.001	<.001	3	5
LSCC	SCML2 →	+0.926	+0.800	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,331 associations by consensus.

WNK2 vs PODXL2 — HNSC

Explore this scatter interactively →