WNK2

Across TCGA patient cohorts, WNK2 mutation is significantly associated with the RNA expression of many other genes, with 5,954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK2-associated genes across cancer lineages are EME1, DBF4B, and DHRS11. Each is linked with WNK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both WNK2-to-partner and partner-to-WNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by WNK2-low versus WNK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK2→partner) and Y-score (partner→WNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.516	+2.332	<.001	<.001	3	5
UCEC	DBF4B →	+0.353	+1.917	<.001	.001	3	5
HNSC	DHRS11 →	+0.670	+3.222	<.001	.009	3	4
UCEC	MYO19 →	+0.377	+1.584	<.001	<.001	3	4
UCEC	PHF5A →	+0.420	+2.115	<.001	<.001	3	4
UCEC	MRPL37 →	+0.287	+1.533	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,954 associations by consensus.

EME1 by WNK2 expression — UCEC

Explore this box plot interactively →