WNK2

Across TCGA patient cohorts, WNK2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WNK2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and MEK1. Each is linked with WNK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WNK2-to-partner and partner-to-WNK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by WNK2-low versus WNK2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WNK2→partner) and Y-score (partner→WNK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	4E-BP1 →	+0.300	+2.824	.043	.036	3	4
UCEC	Cyclin-B1 →	+0.436	+3.169	.007	<.001	3	4
UCEC	MEK1 →	+0.389	+2.662	<.001	<.001	3	3
COAD	PCNA →	+0.184	+3.008	.045	<.001	3	3
UCEC	ERK2 →	+0.173	+2.169	.001	.002	3	3
STAD	Annexin_VII →	-0.153	-2.321	.039	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

4E-BP1 by WNK2 expression — BLCA

Explore this box plot interactively →