WLS

Across TCGA patient cohorts, WLS protein abundance is significantly associated with the RNA expression of many other genes, with 11,143 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible WLS-associated genes across cancer lineages are GNG12-AS1, MIR1262, and CTBP2P8. Each is linked with WLS in more than 7 cancer types. Because this analysis shows association rather than direction, both WLS-to-partner and partner-to-WLS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WLS versus GNG12-AS1 in LUAD, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WLS→partner) and Y-score (partner→WLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GNG12-AS1 →	+0.818	+0.585	<.001	<.001	3	8
LUAD	MIR1262 →	+1.004	+0.647	<.001	<.001	3	5
CCRCC	CTBP2P8 →	+1.042	+0.576	<.001	<.001	3	5
OV	DIRAS3 →	+0.938	+0.432	.004	.005	3	4
BRCA	NANOS1 →	+0.939	+0.889	.001	<.001	3	4
COAD	NKD1 →	+2.202	+0.366	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,143 associations by consensus.

WLS vs GNG12-AS1 — LUAD

Explore this scatter interactively →