WLS

Across TCGA patient cohorts, WLS mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WLS-associated genes across cancer lineages are INPP4B, S6_pS240_S244, and 14-3-3_beta. Each is linked with WLS in more than 1 cancer types. Because this analysis shows association rather than direction, both WLS-to-partner and partner-to-WLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by WLS-low versus WLS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WLS→partner) and Y-score (partner→WLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.220	-1.415	.046	.043	3	2
UCEC	S6_pS240_S244 →	+0.308	+1.514	.026	.015	3	2
UCEC	14-3-3_beta →	-0.102	-2.673	.002	.005	3	1
UCEC	eIF4E →	+0.219	+3.906	.002	<.001	3	1
UCEC	ACVRL1 →	-0.118	-1.514	.011	.015	3	1
UCEC	JNK_pT183_Y185 →	-0.175	-3.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

INPP4B by WLS expression — UCEC

Explore this box plot interactively →