WLS

Across TCGA cell cohorts, WLS mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WLS-associated genes across cancer lineages are CLDN17, PTH, and NEUROD2. Each is linked with WLS in more than 1 cancer types. Because this analysis shows association rather than direction, both WLS-to-partner and partner-to-WLS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by WLS-low versus WLS-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WLS→partner) and Y-score (partner→WLS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLDN17 →	+0.018	+5.228	<.001	.005	3	1
LARGE_INTESTINE	PTH →	+0.038	+2.777	<.001	.004	3	1
LARGE_INTESTINE	NEUROD2 →	+0.092	+3.468	.006	.007	3	1
LARGE_INTESTINE	PABPN1L →	+0.029	+3.054	.001	.001	3	1
BLOOD_Leukemia	PAX1 →	+0.034	+5.060	<.001	.001	3	1
BLOOD_Leukemia	ADAM30 →	+0.017	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

CLDN17 by WLS expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →