WIPI2

Across TCGA pan-cancer cohorts, WIPI2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WIPI2 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher WIPI2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WIPI2 expression acts as an unfavorable survival marker.

LUSC, SKCM, and LUAD are the cancer types where WIPI2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.196	0.742	.010	21	view →
SKCM	DFS	Median	III,IV	0.044	0.613	<.001	14	view →
LUAD	OS	Median	III,IV	0.083	0.680	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WIPI2–LUSC (OS)

Open the LUSC breakdown →