WIPI2

Across TCGA patient cohorts, WIPI2 mutation is significantly associated with the RNA expression of many other genes, with 1,137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPI2-associated genes across cancer lineages are IGKV2-40, IGHVIII-2-1, and TMEM212-IT1. Each is linked with WIPI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPI2-to-partner and partner-to-WIPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV2-40 grouped by WIPI2-low versus WIPI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI2→partner) and Y-score (partner→WIPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGKV2-40 →	+0.182	+1.863	.001	.008	3	2
BLCA	IGHVIII-2-1 →	+0.281	+5.177	<.001	.007	3	2
SKCM	TMEM212-IT1 →	+0.041	+4.147	<.001	.008	3	2
LGG	RN7SL260P →	+0.307	+5.291	<.001	.001	3	2
BLCA	TRAJ21 →	+0.801	+5.497	<.001	.004	3	2
COAD	MIR548AS →	+0.441	+5.831	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,137 associations by consensus.

IGKV2-40 by WIPI2 expression — UCEC

Explore this box plot interactively →