WIPI2

Across TCGA cell cohorts, WIPI2 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WIPI2-associated genes across cancer lineages are USP14, CEP76, and ASPN. Each is linked with WIPI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPI2-to-partner and partner-to-WIPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by WIPI2-low versus WIPI2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI2→partner) and Y-score (partner→WIPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.727	+3.067	.002	.009	3	1
LARGE_INTESTINE	CEP76 →	+0.811	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ASPN →	+0.036	+4.011	.001	<.001	3	1
LARGE_INTESTINE	PCCB →	+0.576	+3.125	.003	.008	3	1
LARGE_INTESTINE	ORC2 →	+0.548	+3.299	.001	.004	3	1
LARGE_INTESTINE	BCAS2 →	+0.657	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

USP14 by WIPI2 expression — LARGE_INTESTINE

Explore this box plot interactively →