WIPI2

Across TCGA cell cohorts, WIPI2 mutation is significantly associated with the mutation status of many other genes, with 5,919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WIPI2-associated genes across cancer lineages are IPO8, PITPNM3, and SLC22A17. Each is linked with WIPI2 in more than 3 cancer types. Because this analysis shows association rather than direction, both WIPI2-to-partner and partner-to-WIPI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IPO8 grouped by WIPI2-low versus WIPI2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPI2→partner) and Y-score (partner→WIPI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IPO8 →	+6.014	+6.014	.001	.001	1	4
BLOOD_Lymphoma	PITPNM3 →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	SLC22A17 →	+6.014	+6.014	.001	.001	1	3
BLOOD_Lymphoma	ACE →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	ZNF496 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	STK36 →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,919 associations by consensus.

IPO8 by WIPI2 expression — BLOOD_Lymphoma

Explore this box plot interactively →