WIPF3

Across TCGA pan-cancer cohorts, WIPF3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WIPF3 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher WIPF3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WIPF3 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, HNSC, and OV are the cancer types where WIPF3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Tertile	All	0.870	0.674	.001	18	view →
HNSC	DFS	Median	III,IV	0.752	0.447	.020	5	view →
OV	DFS	Median	All	0.826	1.000	.024	4	view →
UCEC	DFS	Median	All	1.000	0.948	.044	2	view →
LUAD	DFS	Tertile	All	0.385	0.828	.049	1	view →
PDAC	OS	Median	III,IV	0.851	0.663	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

WIPF3–GBM (DFS)

Open the GBM breakdown →