WIPF3

Across TCGA patient cohorts, WIPF3 mutation is significantly associated with the RNA expression of many other genes, with 775 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPF3-associated genes across cancer lineages are FAM30B, OR5B3, and RNU6-382P. Each is linked with WIPF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both WIPF3-to-partner and partner-to-WIPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM30B grouped by WIPF3-low versus WIPF3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF3→partner) and Y-score (partner→WIPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FAM30B →	+0.202	+5.093	.001	.008	3	3
SKCM	OR5B3 →	+0.032	+4.186	<.001	.007	3	2
LUAD	RNU6-382P →	+0.619	+7.930	<.001	.008	3	2
UCEC	UHRF1 →	+0.888	+2.818	.001	.001	3	2
UCEC	VPS37A →	+0.623	+2.818	.001	.001	3	2
UCEC	TLCD3A →	+0.766	+2.818	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 775 associations by consensus.

FAM30B by WIPF3 expression — LUSC

Explore this box plot interactively →