WIPF3

Across TCGA patient cohorts, WIPF3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPF3-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with WIPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPF3-to-partner and partner-to-WIPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by WIPF3-low versus WIPF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF3→partner) and Y-score (partner→WIPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.013	.030	.018	3	1
UCEC	ERK2 →	+0.211	+3.169	.015	.018	3	1
UCEC	JNK2 →	+0.228	+2.000	.011	.032	3	1
UCEC	Lck →	+0.184	+2.700	.042	.006	3	1
UCEC	MEK1 →	+0.472	+3.459	.004	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.210	+2.713	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by WIPF3 expression — UCEC

Explore this box plot interactively →