WIPF3

Across TCGA cell cohorts, WIPF3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WIPF3-associated genes across cancer lineages are SLC32A1, PHOX2B, and GZMK. Each is linked with WIPF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPF3-to-partner and partner-to-WIPF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by WIPF3-low versus WIPF3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF3→partner) and Y-score (partner→WIPF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.773	+3.901	<.001	.006	3	1
BLOOD_Leukemia	PHOX2B →	+0.024	+4.365	<.001	.002	3	1
BLOOD_Leukemia	GZMK →	+0.653	+4.037	<.001	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.966	<.001	<.001	3	1
BLOOD_Leukemia	C16orf92 →	+0.137	+4.037	.001	.004	3	1
BLOOD_Leukemia	INSM2 →	+0.163	+3.769	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SLC32A1 by WIPF3 expression — BLOOD_Leukemia

Explore this box plot interactively →