WIPF2

Across TCGA patient cohorts, WIPF2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPF2-associated genes across cancer lineages are GAPDH, Bak, and 4E-BP1. Each is linked with WIPF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIPF2-to-partner and partner-to-WIPF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by WIPF2-low versus WIPF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF2→partner) and Y-score (partner→WIPF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.608	+2.700	.012	.006	3	2
UCEC	Bak →	+0.267	+2.321	.018	.034	3	2
UCEC	4E-BP1 →	+0.417	+3.029	<.001	.018	3	2
UCEC	Cyclin-E2 →	+0.167	+3.009	.028	.019	3	2
UCEC	eEF2 →	+0.544	+3.321	<.001	.010	3	1
UCEC	FoxM1 →	+0.310	+2.700	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by WIPF2 expression — UCEC

Explore this box plot interactively →