WIPF1

Across TCGA patient cohorts, WIPF1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIPF1-associated genes across cancer lineages are FASN, FoxM1, and Shc_pY317. Each is linked with WIPF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WIPF1-to-partner and partner-to-WIPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by WIPF1-low versus WIPF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIPF1→partner) and Y-score (partner→WIPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.474	+3.008	.019	.019	3	3
UCEC	FoxM1 →	+0.143	+1.321	.047	.005	3	3
UCEC	Shc_pY317 →	-0.151	-1.836	<.001	.001	3	3
UCEC	14-3-3_beta →	-0.083	-2.558	.003	<.001	3	2
UCEC	A-Raf_pS299 →	-0.115	-1.716	<.001	.003	3	2
UCEC	ERK2 →	+0.150	+1.807	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FASN by WIPF1 expression — COAD

Explore this box plot interactively →