WIF1

Across TCGA pan-cancer cohorts, WIF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WIF1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WIF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WIF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where WIF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.917	0.352	.008	14	view →
LSCC	OS	Median	II,III,IV	0.918	0.740	.013	10	view →
LUAD	DFS	Median	All	0.851	0.940	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

WIF1–HNSC (DFS)

Open the HNSC breakdown →