WIF1

Across TCGA patient cohorts, WIF1 mutation is significantly associated with the RNA expression of many other genes, with 3,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIF1-associated genes across cancer lineages are SNORD115-21, OR8B6P, and GAGE12H. Each is linked with WIF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both WIF1-to-partner and partner-to-WIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-21 grouped by WIF1-low versus WIF1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIF1→partner) and Y-score (partner→WIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SNORD115-21 →	+0.583	+4.544	<.001	.009	3	3
GBM	OR8B6P →	+0.088	+6.614	<.001	<.001	3	2
LIHC	GAGE12H →	+0.193	+5.305	<.001	.003	3	2
UCEC	MIR6803 →	+0.094	+4.086	<.001	.005	3	2
LIHC	LINC02131 →	+0.192	+5.305	<.001	.003	3	2
UCEC	PIGU →	+0.327	+2.290	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,451 associations by consensus.

SNORD115-21 by WIF1 expression — LIHC

Explore this box plot interactively →