WIF1

Across TCGA patient cohorts, WIF1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WIF1-associated genes across cancer lineages are MEK1, Notch1, and ATM. Each is linked with WIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WIF1-to-partner and partner-to-WIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by WIF1-low versus WIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WIF1→partner) and Y-score (partner→WIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.502	+3.087	<.001	<.001	3	2
UCEC	Notch1 →	+0.160	+1.906	.004	.016	3	2
UCEC	ATM →	-0.491	-3.156	.007	.018	3	2
UCEC	Caspase-8 →	-0.251	-2.780	.013	.003	3	2
UCEC	C-Raf →	+0.211	+2.459	<.001	.019	3	2
UCEC	14-3-3_beta →	-0.094	-3.143	.020	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by WIF1 expression — UCEC

Explore this box plot interactively →