WHRN

Across TCGA pan-cancer cohorts, WHRN Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated WHRN data layer compared with 27 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher WHRN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WHRN expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

ACC, LUAD, and SARC are the cancer types where WHRN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.273	0.802	.017	15	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	OS	Median	III,IV	1.000	0.351	.039	3	view →
HNSC	OS	Median	III,IV	0.174	0.673	.048	3	view →
UCEC	DFS	Median	II,III,IV	0.906	0.441	.048	2	view →
LUSC	DFS	Median	All	1.000	0.381	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

WHRN–ACC (OS)

Open the ACC breakdown →