WHRN

Across TCGA patient cohorts, WHRN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,164 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible WHRN-associated GO terms across cancer lineages are Cerebellar Purkinje cell layer morphogenesis, Cerebellar Purkinje cell layer formation, and Obsolete histone methylation. Each is linked with WHRN in more than 28 cancer types. Because this analysis shows association rather than direction, both WHRN-to-partner and partner-to-WHRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cerebellar Purkinje cell layer morphogenesis grouped by WHRN-low versus WHRN-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WHRN→partner) and Y-score (partner→WHRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Cerebellar Purkinje cell layer morphogenesis →	+0.131	+1.319	<.001	.003	2	29
CHOL	Cerebellar Purkinje cell layer formation →	+0.080	+1.623	<.001	<.001	3	28
SCLC	Obsolete histone methylation →	+0.164	+1.799	<.001	<.001	2	27
CHOL	Hindbrain morphogenesis →	+0.049	+1.297	<.001	<.001	3	26
SCLC	Cerebellar Purkinje cell layer development →	+0.128	+1.253	<.001	.006	2	27
DLBC	Cytoskeleton-dependent intracellular transport →	+0.046	+1.544	.003	.003	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,164 associations by consensus.

Cerebellar Purkinje cell layer morphogenesis by WHRN expression — SCLC

Explore this box plot interactively →