WHRN

Across TCGA patient cohorts, WHRN mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WHRN-associated genes across cancer lineages are MSH2, ATM, and Cyclin-B1. Each is linked with WHRN in more than 1 cancer types. Because this analysis shows association rather than direction, both WHRN-to-partner and partner-to-WHRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by WHRN-low versus WHRN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WHRN→partner) and Y-score (partner→WHRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.341	-2.433	<.001	.018	3	2
UCEC	ATM →	-0.633	-2.687	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.616	+2.584	.004	.001	3	2
UCEC	eIF4E →	+0.193	+1.678	.016	.023	3	1
UCEC	A-Raf_pS299 →	-0.140	-2.584	.002	.010	3	1
UCEC	ERK2 →	+0.271	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MSH2 by WHRN expression — UCEC

Explore this box plot interactively →