WHRN

Across TCGA cell cohorts, WHRN mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WHRN-associated genes across cancer lineages are LCN9, LLGL1, and R3HDML. Each is linked with WHRN in more than 1 cancer types. Because this analysis shows association rather than direction, both WHRN-to-partner and partner-to-WHRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN9 grouped by WHRN-low versus WHRN-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WHRN→partner) and Y-score (partner→WHRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LCN9 →	+0.079	+5.169	<.001	.005	3	2
LARGE_INTESTINE	LLGL1 →	+0.653	+3.526	.006	<.001	3	2
BLOOD_Lymphoma	R3HDML →	+0.004	+4.209	<.001	.001	3	1
BLOOD_Lymphoma	CABP5 →	+0.009	+3.867	<.001	.002	3	1
BLOOD_Lymphoma	BARHL1 →	+0.038	+3.869	<.001	.002	3	1
BLOOD_Lymphoma	TMEM95 →	+0.238	+3.321	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

LCN9 by WHRN expression — BREAST

Explore this box plot interactively →