WHAMMP2

Across TCGA pan-cancer cohorts, WHAMMP2 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated WHAMMP2 data layer compared with 1 for mutation status.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher WHAMMP2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated WHAMMP2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and ACC show a favorable association.

PAAD, LGG, and ACC are the cancer types where WHAMMP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.609	0.351	<.001	69	view →
LGG	DFS	Median	All	0.658	0.805	<.001	53	view →
ACC	OS	Median	III,IV	0.690	0.245	.005	36	view →
STAD	DFS	Quartile	All	0.464	0.645	.007	35	view →
KIRP	DFS	Median	All	0.918	0.581	.007	22	view →
PRAD	DFS	Tertile	All	0.690	0.853	.015	14	view →
UVM	DFS	Tertile	III,IV	0.347	1.000	.006	11	view →
SARC	DFS	Tertile	All	0.459	0.213	.009	9	view →
THYM	DFS	Tertile	III,IV	1.000	0.525	.032	6	view →
OV	OS	Tertile	IV	0.693	0.882	.028	6	view →
DLBC	DFS	Quartile	III,IV	0.074	0.984	.038	6	view →
UCEC	OS	Tertile	All	0.837	0.898	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

WHAMMP2–PAAD (DFS)

Open the PAAD breakdown →