WHAMM

Across TCGA pan-cancer cohorts, WHAMM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WHAMM data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WHAMM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WHAMM expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

LUAD, GBM, and PDAC are the cancer types where WHAMM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.862	0.998	.009	28	view →
GBM	OS	Median	All	1.000	0.763	.004	4	view →
PDAC	OS	Quartile	All	0.719	0.423	.024	4	view →
LSCC	DFS	Tertile	III,IV	0.592	0.972	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WHAMM–LUAD (DFS)

Open the LUAD breakdown →