WHAMM

Across TCGA patient cohorts, WHAMM mutation is significantly associated with the RNA expression of many other genes, with 820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WHAMM-associated genes across cancer lineages are PSAT1P4, RNA5SP414, and LINC02438. Each is linked with WHAMM in more than 1 cancer types. Because this analysis shows association rather than direction, both WHAMM-to-partner and partner-to-WHAMM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by WHAMM-low versus WHAMM-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WHAMM→partner) and Y-score (partner→WHAMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PSAT1P4 →	+0.095	+3.918	<.001	.001	3	2
UCEC	RNA5SP414 →	+0.332	+1.740	.004	.009	3	2
UCEC	LINC02438 →	+0.475	+2.439	.001	.001	3	2
UCEC	RNA5SP408 →	+0.248	+2.379	.001	.001	3	2
UCEC	RNA5SP413 →	+0.728	+1.736	<.001	.002	3	2
CESC	LINC02559 →	+1.327	+5.342	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 820 associations by consensus.

PSAT1P4 by WHAMM expression — CESC

Explore this box plot interactively →