WHAMM

Across TCGA patient cohorts, WHAMM mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WHAMM-associated genes across cancer lineages are eEF2, MEK1, and MSH2. Each is linked with WHAMM in more than 1 cancer types. Because this analysis shows association rather than direction, both WHAMM-to-partner and partner-to-WHAMM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by WHAMM-low versus WHAMM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WHAMM→partner) and Y-score (partner→WHAMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.304	+1.874	.018	.049	3	2
UCEC	MEK1 →	+0.419	+4.000	.001	<.001	3	2
UCEC	MSH2 →	-0.221	-1.848	.007	.049	3	2
UCEC	VHL →	-0.951	-2.700	<.001	.005	3	2
UCEC	ASNS →	+0.427	+2.115	.001	.016	3	2
UCEC	ATM →	-0.542	-1.925	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by WHAMM expression — UCEC

Explore this box plot interactively →