WHAMM

Across TCGA cell cohorts, WHAMM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,480 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WHAMM-associated GO terms across cancer lineages are Endosomal transport, Regulation of transforming growth factor beta3 production, and Regulation of nucleocytoplasmic transport. Each is linked with WHAMM in more than 11 cancer types. Because this analysis shows association rather than direction, both WHAMM-to-partner and partner-to-WHAMM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by WHAMM-low versus WHAMM-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WHAMM→partner) and Y-score (partner→WHAMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endosomal transport →	+0.074	+0.734	.001	<.001	3	12
OVARY	Regulation of transforming growth factor beta3 production →	+0.196	+0.708	<.001	<.001	3	12
BONE	Regulation of nucleocytoplasmic transport →	+0.063	+0.613	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein stabilization →	+0.062	+0.631	<.001	.003	3	12
LIVER	Cytoplasmic pattern recognition receptor signaling pathway →	+0.094	+0.451	<.001	.003	3	11
BONE	Cytosolic transport →	+0.091	+0.721	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,480 associations by consensus.

Endosomal transport by WHAMM expression — BONE

Explore this box plot interactively →