WHAMM

Across TCGA cell cohorts, WHAMM mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WHAMM-associated genes across cancer lineages are OR10W1, CST9L, and CASP14. Each is linked with WHAMM in more than 1 cancer types. Because this analysis shows association rather than direction, both WHAMM-to-partner and partner-to-WHAMM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by WHAMM-low versus WHAMM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WHAMM→partner) and Y-score (partner→WHAMM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	2
BLOOD_Leukemia	CST9L →	+0.319	+3.684	<.001	.004	3	1
BLOOD_Leukemia	CASP14 →	+0.033	+4.240	<.001	.007	3	1
BLOOD_Leukemia	OR11H1 →	+0.068	+4.201	<.001	.001	3	1
BLOOD_Leukemia	HBZ →	+2.069	+3.820	.007	.004	3	1
BLOOD_Leukemia	TRPC6 →	+0.991	+4.169	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

OR10W1 by WHAMM expression — LARGE_INTESTINE

Explore this box plot interactively →