WFS1

Across TCGA pan-cancer cohorts, WFS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WFS1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WFS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated WFS1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where WFS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.854	1.000	.016	16	view →
LUAD	DFS	Quartile	II,III,IV	0.779	0.936	.007	12	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	8	view →
CCRCC	DFS	Quartile	III,IV	0.104	0.985	.038	7	view →
LSCC	DFS	Quartile	II,III,IV	0.651	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WFS1–HNSC (DFS)

Open the HNSC breakdown →