WFS1

Across TCGA patient cohorts, WFS1 protein abundance is significantly associated with the protein abundance of many other proteins, with 30,851 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WFS1-associated proteins across cancer lineages are WFS1_S235, RUSF1, and WFS1_S32. Each is linked with WFS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both WFS1-to-partner and partner-to-WFS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, WFS1 versus WFS1_S235 in BRCA, with a Pearson correlation of 0.78.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WFS1→partner) and Y-score (partner→WFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WFS1_S235 →	+1.617	+0.663	<.001	<.001	3	9
BRCA	RUSF1 →	+0.499	+0.362	<.001	<.001	3	9
LSCC	WFS1_S32 →	+1.141	+0.357	<.001	.002	2	9
PDAC	LEMD2 →	+0.504	+0.459	<.001	<.001	3	7
BRCA	CANX_S564 →	+0.915	+0.398	<.001	<.001	3	7
UCEC	DAD1 →	+0.695	+0.447	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 30,851 associations by consensus.

WFS1 vs WFS1_S235 — BRCA

Explore this scatter interactively →